Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function
Identifieur interne : 000843 ( Main/Exploration ); précédent : 000842; suivant : 000844Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function
Auteurs : Omar Khadrawy ; Samuel Gebremedhn ; Dessie Salilew-Wondim ; Mohamed Omar Taqi ; Christiane Neuhoff ; Ernst Tholen ; Michael Hoelker [Allemagne] ; Karl Schellander [Allemagne] ; Dawit Tesfaye [Allemagne]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2019.
Abstract
Nrf2 is a redox sensitive transcription factor regulating the expression of antioxidant genes as defense mechanism against various stressors. The aim of this study is to investigate the potential role of noncoding miRNAs as endogenous and quercetin as exogenous regulators of Nrf2 pathway in bovine granulosa cells. For this cultured granulosa cells were used for modulation of miRNAs (miR-28, 153 and miR-708) targeting the bovine Nrf2 and supplementation of quercentin to investigate the regulatory mechanisms of the Nrf2 antioxidant system. Moreover, cultured cells were treated with hydrogen peroxide to induce oxidative stress in those cells. Our results showed that, oxidative stress activated the expression of Nrf2 as a defense mechanism, while suppressing the expression of those miRNAs. Overexpression of those miRNAs resulted in downregulation of Nrf2 expression resulted in higher ROS accumulation, reduced mitochondrial activity and cellular proliferation. Quercetin supplementation showed its protective role against oxidative stress induced by H2O2 by inducing the expression of antioxidant enzymes. In conclusion, this study highlighted the involvement of miR-153, miR-28 and miR-708 in regulatory network of Nrf2 mediated antioxidant system in bovine granulosa cells function. Furthermore, quercetin at a low dose played a protective role in bovine granulosa cells against oxidative stress damage.
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DOI: 10.3390/ijms20071635
PubMed: 30986945
PubMed Central: 6480527
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last="Gebremedhn">Samuel Gebremedhn</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Salilew Wondim, Dessie" sort="Salilew Wondim, Dessie" uniqKey="Salilew Wondim D" first="Dessie" last="Salilew-Wondim">Dessie Salilew-Wondim</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Taqi, Mohamed Omar" sort="Taqi, Mohamed Omar" uniqKey="Taqi M" first="Mohamed Omar" last="Taqi">Mohamed Omar Taqi</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Neuhoff, Christiane" sort="Neuhoff, Christiane" uniqKey="Neuhoff C" first="Christiane" last="Neuhoff">Christiane Neuhoff</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Tholen, Ernst" sort="Tholen, Ernst" uniqKey="Tholen E" first="Ernst" last="Tholen">Ernst Tholen</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Hoelker, Michael" sort="Hoelker, Michael" uniqKey="Hoelker M" first="Michael" last="Hoelker">Michael Hoelker</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> 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Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Gebremedhn, Samuel" sort="Gebremedhn, Samuel" uniqKey="Gebremedhn S" first="Samuel" last="Gebremedhn">Samuel Gebremedhn</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Salilew Wondim, Dessie" sort="Salilew Wondim, Dessie" uniqKey="Salilew Wondim D" first="Dessie" last="Salilew-Wondim">Dessie Salilew-Wondim</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Taqi, Mohamed Omar" sort="Taqi, Mohamed Omar" uniqKey="Taqi M" first="Mohamed Omar" last="Taqi">Mohamed Omar Taqi</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Neuhoff, Christiane" sort="Neuhoff, Christiane" uniqKey="Neuhoff C" first="Christiane" last="Neuhoff">Christiane Neuhoff</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Tholen, Ernst" sort="Tholen, Ernst" uniqKey="Tholen E" first="Ernst" last="Tholen">Ernst Tholen</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation></author><author><name sortKey="Hoelker, Michael" sort="Hoelker, Michael" uniqKey="Hoelker M" first="Michael" last="Hoelker">Michael Hoelker</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijms-20-01635">Teaching and Research Station Frankenforst, Faculty of Agriculture, University of Bonn, 53639 Königswinter, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Teaching and Research Station Frankenforst, Faculty of Agriculture, University of Bonn, 53639 Königswinter</wicri:regionArea><wicri:noRegion>53639 Königswinter</wicri:noRegion><wicri:noRegion>53639 Königswinter</wicri:noRegion><wicri:noRegion>53639 Königswinter</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="af3-ijms-20-01635">Center of Integrated Dairy Research, University of Bonn, 53175 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Integrated Dairy Research, University of Bonn, 53175 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schellander, Karl" sort="Schellander, Karl" uniqKey="Schellander K" first="Karl" last="Schellander">Karl Schellander</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="af3-ijms-20-01635">Center of Integrated Dairy Research, University of Bonn, 53175 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Integrated Dairy Research, University of Bonn, 53175 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Tesfaye, Dawit" sort="Tesfaye, Dawit" uniqKey="Tesfaye D" first="Dawit" last="Tesfaye">Dawit Tesfaye</name><affiliation><nlm:aff id="af1-ijms-20-01635">Institute of Animal Science, Department of Animal Breeding and Husbandry, University of Bonn, 53175 Bonn, Germany;<email>okha@itw.uni-bonn.de</email> (O.K.);<email>seta@itw.uni-bonn.de</email> (S.G.);<email>dsal@itw.uni-bonn.de</email> (D.S.-W.);<email>mtaq@itw.uni-bonn.de</email> (M.O.T.);<email>cneu@itw.uni-bonn.de</email> (C.N.);<email>etho@itw.uni-bonn.de</email> (E.T.);<email>mhoe@itw.uni-bonn.de</email> (M.H.);<email>ksch@itw.uni-bonn.de</email> (K.S.)</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="af3-ijms-20-01635">Center of Integrated Dairy Research, University of Bonn, 53175 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Integrated Dairy Research, University of Bonn, 53175 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nrf2 is a redox sensitive transcription factor regulating the expression of antioxidant genes as defense mechanism against various stressors. The aim of this study is to investigate the potential role of noncoding miRNAs as endogenous and quercetin as exogenous regulators of Nrf2 pathway in bovine granulosa cells. For this cultured granulosa cells were used for modulation of miRNAs (miR-28, 153 and miR-708) targeting the bovine Nrf2 and supplementation of quercentin to investigate the regulatory mechanisms of the Nrf2 antioxidant system. Moreover, cultured cells were treated with hydrogen peroxide to induce oxidative stress in those cells. Our results showed that, oxidative stress activated the expression of Nrf2 as a defense mechanism, while suppressing the expression of those miRNAs. Overexpression of those miRNAs resulted in downregulation of Nrf2 expression resulted in higher ROS accumulation, reduced mitochondrial activity and cellular proliferation. Quercetin supplementation showed its protective role against oxidative stress induced by H<sub>2</sub>O<sub>2</sub> by inducing the expression of antioxidant enzymes. In conclusion, this study highlighted the involvement of miR-153, miR-28 and miR-708 in regulatory network of Nrf2 mediated antioxidant system in bovine granulosa cells function. Furthermore, quercetin at a low dose played a protective role in bovine granulosa cells against oxidative stress damage.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Son, W Y" uniqKey="Son W">W.Y. Son</name></author><author><name sortKey="Das, M" uniqKey="Das M">M. Das</name></author><author><name sortKey="Shalom Paz, E" uniqKey="Shalom Paz E">E. Shalom-Paz</name></author><author><name sortKey="Holzer, H" uniqKey="Holzer H">H. Holzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garratt, M" uniqKey="Garratt M">M. Garratt</name></author><author><name sortKey="Vasilaki, A" uniqKey="Vasilaki A">A. Vasilaki</name></author><author><name sortKey="Stockley, P" uniqKey="Stockley P">P. Stockley</name></author><author><name sortKey="Mcardle, F" uniqKey="Mcardle F">F. McArdle</name></author><author><name sortKey="Jackson, M" uniqKey="Jackson M">M. Jackson</name></author><author><name sortKey="Hurst, J L" uniqKey="Hurst J">J.L. Hurst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Celi, P" uniqKey="Celi P">P. Celi</name></author><author><name sortKey="Gabai, G" uniqKey="Gabai G">G. Gabai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Metcalfe, N B" uniqKey="Metcalfe N">N.B. Metcalfe</name></author><author><name sortKey="Alonso Alvarez, C" uniqKey="Alonso Alvarez C">C. Alonso-Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Persson, T" uniqKey="Persson T">T. Persson</name></author><author><name sortKey="Popescu, B O" uniqKey="Popescu B">B.O. Popescu</name></author><author><name sortKey="Cedazo Minguez, A" uniqKey="Cedazo Minguez A">A. Cedazo-Minguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aruoma, O I" uniqKey="Aruoma O">O.I. Aruoma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valko, M" uniqKey="Valko M">M. Valko</name></author><author><name sortKey="Leibfritz, D" uniqKey="Leibfritz D">D. Leibfritz</name></author><author><name sortKey="Moncol, J" uniqKey="Moncol J">J. Moncol</name></author><author><name sortKey="Cronin, M T D" uniqKey="Cronin M">M.T.D. Cronin</name></author><author><name sortKey="Mazur, M" uniqKey="Mazur M">M. Mazur</name></author><author><name sortKey="Telser, J" uniqKey="Telser J">J. Telser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trachootham, D" uniqKey="Trachootham D">D. Trachootham</name></author><author><name sortKey="Alexandre, J" uniqKey="Alexandre J">J. Alexandre</name></author><author><name sortKey="Huang, P" uniqKey="Huang P">P. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, A U" uniqKey="Khan A">A.U. Khan</name></author><author><name sortKey="Wilson, T" uniqKey="Wilson T">T. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finkel, T" uniqKey="Finkel T">T. Finkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allen, R G" uniqKey="Allen R">R.G. Allen</name></author><author><name sortKey="Tresini, M" uniqKey="Tresini M">M. Tresini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaube, S K" uniqKey="Chaube S">S.K. Chaube</name></author><author><name sortKey="Prasad, P V" uniqKey="Prasad P">P.V. Prasad</name></author><author><name sortKey="Thakur, S C" uniqKey="Thakur S">S.C. Thakur</name></author><author><name sortKey="Shrivastav, T G" uniqKey="Shrivastav T">T.G. Shrivastav</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Combelles, C M H" uniqKey="Combelles C">C.M.H. Combelles</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S. Gupta</name></author><author><name sortKey="Agarwal, A" uniqKey="Agarwal A">A. Agarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agarwal, A" uniqKey="Agarwal A">A. Agarwal</name></author><author><name sortKey="Allamaneni, S S R" uniqKey="Allamaneni S">S.S.R. Allamaneni</name></author><author><name sortKey="Nallella, K P" uniqKey="Nallella K">K.P. Nallella</name></author><author><name sortKey="George, A T" uniqKey="George A">A.T. George</name></author><author><name sortKey="Mascha, E" uniqKey="Mascha E">E. Mascha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarez, J G" uniqKey="Alvarez J">J.G. Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, Q" uniqKey="Lai Q">Q. Lai</name></author><author><name sortKey="Xiang, W" uniqKey="Xiang W">W. Xiang</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G. Zhu</name></author><author><name sortKey="Xiong, C" uniqKey="Xiong C">C. Xiong</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, L F" uniqKey="Liang L">L.-F. Liang</name></author><author><name sortKey="Qi, S T" uniqKey="Qi S">S.-T. Qi</name></author><author><name sortKey="Xian, Y X" uniqKey="Xian Y">Y.-X. Xian</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L. Huang</name></author><author><name sortKey="Sun, X F" uniqKey="Sun X">X.-F. Sun</name></author><author><name sortKey="Wang, W H" uniqKey="Wang W">W.-H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chanas, S A" uniqKey="Chanas S">S.A. Chanas</name></author><author><name sortKey="Jiang, Q" uniqKey="Jiang Q">Q. Jiang</name></author><author><name sortKey="Mcmahon, M" uniqKey="Mcmahon M">M. McMahon</name></author><author><name sortKey="Mcwalter, G K" uniqKey="Mcwalter G">G.K. McWalter</name></author><author><name sortKey="Mclellan, L I" uniqKey="Mclellan L">L.I. McLellan</name></author><author><name sortKey="Elcombe, C R" uniqKey="Elcombe C">C.R. Elcombe</name></author><author><name sortKey="Henderson, C J" uniqKey="Henderson C">C.J. Henderson</name></author><author><name sortKey="Wolf, C R" uniqKey="Wolf C">C.R. Wolf</name></author><author><name sortKey="Moffat, G J" uniqKey="Moffat G">G.J. Moffat</name></author><author><name sortKey="Itoh, K" uniqKey="Itoh K">K. Itoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwak, M K" uniqKey="Kwak M">M.K. Kwak</name></author><author><name sortKey="Wakabayashi, N" uniqKey="Wakabayashi N">N. Wakabayashi</name></author><author><name sortKey="Itoh, K" uniqKey="Itoh K">K. Itoh</name></author><author><name sortKey="Motohashi, H" uniqKey="Motohashi H">H. Motohashi</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author><author><name sortKey="Kensler, T W" uniqKey="Kensler T">T.W. Kensler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmahon, M" uniqKey="Mcmahon M">M. McMahon</name></author><author><name sortKey="Itoh, K" uniqKey="Itoh K">K. Itoh</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author><author><name sortKey="Chanas, S A" uniqKey="Chanas S">S.A. Chanas</name></author><author><name sortKey="Henderson, C J" uniqKey="Henderson C">C.J. Henderson</name></author><author><name sortKey="Mclellan, L I" uniqKey="Mclellan L">L.I. McLellan</name></author><author><name sortKey="Wolf, C R" uniqKey="Wolf C">C.R. Wolf</name></author><author><name sortKey="Cavin, C" uniqKey="Cavin C">C. Cavin</name></author><author><name sortKey="Hayes, J D" uniqKey="Hayes J">J.D. Hayes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayes, J D" uniqKey="Hayes J">J.D. Hayes</name></author><author><name sortKey="Dinkova Kostova, A T" uniqKey="Dinkova Kostova A">A.T. Dinkova-Kostova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmahon, M" uniqKey="Mcmahon M">M. McMahon</name></author><author><name sortKey="Itoh, K" uniqKey="Itoh K">K. Itoh</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author><author><name sortKey="Hayes, J D" uniqKey="Hayes J">J.D. Hayes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itoh, K" uniqKey="Itoh K">K. Itoh</name></author><author><name sortKey="Chiba, T" uniqKey="Chiba T">T. Chiba</name></author><author><name sortKey="Takahashi, S" uniqKey="Takahashi S">S. Takahashi</name></author><author><name sortKey="Ishii, T" uniqKey="Ishii T">T. Ishii</name></author><author><name sortKey="Igarashi, K" uniqKey="Igarashi K">K. Igarashi</name></author><author><name sortKey="Katoh, Y" uniqKey="Katoh Y">Y. Katoh</name></author><author><name sortKey="Oyake, T" uniqKey="Oyake T">T. Oyake</name></author><author><name sortKey="Hayashi, N" uniqKey="Hayashi N">N. Hayashi</name></author><author><name sortKey="Satoh, K" uniqKey="Satoh K">K. Satoh</name></author><author><name sortKey="Hatayama, I" uniqKey="Hatayama I">I. Hatayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kensler, T W" uniqKey="Kensler T">T.W. Kensler</name></author><author><name sortKey="Wakabayashi, N" uniqKey="Wakabayashi N">N. Wakabayashi</name></author><author><name sortKey="Biswal, S" uniqKey="Biswal S">S. Biswal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalayarasan, S" uniqKey="Kalayarasan S">S. Kalayarasan</name></author><author><name sortKey="Prabhu, P N" uniqKey="Prabhu P">P.N. Prabhu</name></author><author><name sortKey="Sriram, N" uniqKey="Sriram N">N. Sriram</name></author><author><name sortKey="Manikandan, R" uniqKey="Manikandan R">R. Manikandan</name></author><author><name sortKey="Arumugam, M" uniqKey="Arumugam M">M. Arumugam</name></author><author><name sortKey="Sudhandiran, G" uniqKey="Sudhandiran G">G. Sudhandiran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, K" uniqKey="Taguchi K">K. Taguchi</name></author><author><name sortKey="Motohashi, H" uniqKey="Motohashi H">H. Motohashi</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amin, A" uniqKey="Amin A">A. Amin</name></author><author><name sortKey="Gad, A" uniqKey="Gad A">A. Gad</name></author><author><name sortKey="Salilew Wondim, D" uniqKey="Salilew Wondim D">D. Salilew-Wondim</name></author><author><name sortKey="Prastowo, S" uniqKey="Prastowo S">S. Prastowo</name></author><author><name sortKey="Held, E" uniqKey="Held E">E. Held</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Rings, F" uniqKey="Rings F">F. Rings</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Looft, C" uniqKey="Looft C">C. Looft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saeed Zidane, M" uniqKey="Saeed Zidane M">M. Saeed-Zidane</name></author><author><name sortKey="Linden, L" uniqKey="Linden L">L. Linden</name></author><author><name sortKey="Salilew Wondim, D" uniqKey="Salilew Wondim D">D. Salilew-Wondim</name></author><author><name sortKey="Held, E" uniqKey="Held E">E. Held</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Schellander, K" uniqKey="Schellander K">K. Schellander</name></author><author><name sortKey="Tesfaye, D" uniqKey="Tesfaye D">D. Tesfaye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Yu, S" uniqKey="Yu S">S. Yu</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Kong, A N T" uniqKey="Kong A">A.-N.T. Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartel, D P" uniqKey="Bartel D">D.P. Bartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartel, D P" uniqKey="Bartel D">D.P. Bartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Preusse, M" uniqKey="Preusse M">M. Preusse</name></author><author><name sortKey="Theis, F J" uniqKey="Theis F">F.J. Theis</name></author><author><name sortKey="Mueller, N S" uniqKey="Mueller N">N.S. Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mor, E" uniqKey="Mor E">E. Mor</name></author><author><name sortKey="Cabilly, Y" uniqKey="Cabilly Y">Y. Cabilly</name></author><author><name sortKey="Goldshmit, Y" uniqKey="Goldshmit Y">Y. Goldshmit</name></author><author><name sortKey="Zalts, H" uniqKey="Zalts H">H. Zalts</name></author><author><name sortKey="Modai, S" uniqKey="Modai S">S. Modai</name></author><author><name sortKey="Edry, L" uniqKey="Edry L">L. Edry</name></author><author><name sortKey="Elroy Stein, O" uniqKey="Elroy Stein O">O. Elroy-Stein</name></author><author><name sortKey="Shomron, N" uniqKey="Shomron N">N. Shomron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauer, E" uniqKey="Sauer E">E. Sauer</name></author><author><name sortKey="Extra, A" uniqKey="Extra A">A. Extra</name></author><author><name sortKey="Cachee, P" uniqKey="Cachee P">P. Cachée</name></author><author><name sortKey="Courts, C" uniqKey="Courts C">C. Courts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwig, N" uniqKey="Ludwig N">N. Ludwig</name></author><author><name sortKey="Leidinger, P" uniqKey="Leidinger P">P. Leidinger</name></author><author><name sortKey="Becker, K" uniqKey="Becker K">K. Becker</name></author><author><name sortKey="Backes, C" uniqKey="Backes C">C. Backes</name></author><author><name sortKey="Fehlmann, T" uniqKey="Fehlmann T">T. Fehlmann</name></author><author><name sortKey="Pallasch, C" uniqKey="Pallasch C">C. Pallasch</name></author><author><name sortKey="Rheinheimer, S" uniqKey="Rheinheimer S">S. Rheinheimer</name></author><author><name sortKey="Meder, B" uniqKey="Meder B">B. Meder</name></author><author><name sortKey="St Hler, C" uniqKey="St Hler C">C. Stähler</name></author><author><name sortKey="Meese, E" uniqKey="Meese E">E. Meese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blenkiron, C" uniqKey="Blenkiron C">C. Blenkiron</name></author><author><name sortKey="Miska, E A" uniqKey="Miska E">E.A. Miska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andreas, E" uniqKey="Andreas E">E. Andreas</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Schellander, K" uniqKey="Schellander K">K. Schellander</name></author><author><name sortKey="Tesfaye, D" uniqKey="Tesfaye D">D. Tesfaye</name></author><author><name sortKey="Salilew Wondim, D" uniqKey="Salilew Wondim D">D. Salilew-Wondim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gebremedhn, S" uniqKey="Gebremedhn S">S. Gebremedhn</name></author><author><name sortKey="Salilew Wondim, D" uniqKey="Salilew Wondim D">D. Salilew-Wondim</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Rings, F" uniqKey="Rings F">F. Rings</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Schellander, K" uniqKey="Schellander K">K. Schellander</name></author><author><name sortKey="Tesfaye, D" uniqKey="Tesfaye D">D. Tesfaye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pande, H O" uniqKey="Pande H">H.O. Pande</name></author><author><name sortKey="Tesfaye, D" uniqKey="Tesfaye D">D. Tesfaye</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Gebremedhn, S" uniqKey="Gebremedhn S">S. Gebremedhn</name></author><author><name sortKey="Held, E" uniqKey="Held E">E. Held</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Schellander, K" uniqKey="Schellander K">K. Schellander</name></author><author><name sortKey="Wondim, D S" uniqKey="Wondim D">D.S. Wondim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hossain, M M" uniqKey="Hossain M">M.M. Hossain</name></author><author><name sortKey="Sohel, M M H" uniqKey="Sohel M">M.M.H. Sohel</name></author><author><name sortKey="Schellander, K" uniqKey="Schellander K">K. Schellander</name></author><author><name sortKey="Tesfaye, D" uniqKey="Tesfaye D">D. Tesfaye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, L" uniqKey="Lei L">L. Lei</name></author><author><name sortKey="Jin, S" uniqKey="Jin S">S. Jin</name></author><author><name sortKey="Gonzalez, G" uniqKey="Gonzalez G">G. Gonzalez</name></author><author><name sortKey="Behringer, R R" uniqKey="Behringer R">R.R. Behringer</name></author><author><name sortKey="Woodruff, T K" uniqKey="Woodruff T">T.K. Woodruff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahrami, A" uniqKey="Bahrami A">A. Bahrami</name></author><author><name sortKey="Miraie Ashtiani, S R" uniqKey="Miraie Ashtiani S">S.R. Miraie-Ashtiani</name></author><author><name sortKey="Sadeghi, M" uniqKey="Sadeghi M">M. Sadeghi</name></author><author><name sortKey="Najafi, A" uniqKey="Najafi A">A. Najafi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilchrist, G C" uniqKey="Gilchrist G">G.C. Gilchrist</name></author><author><name sortKey="Tscherner, A" uniqKey="Tscherner A">A. Tscherner</name></author><author><name sortKey="Nalpathamkalam, T" uniqKey="Nalpathamkalam T">T. Nalpathamkalam</name></author><author><name sortKey="Merico, D" uniqKey="Merico D">D. Merico</name></author><author><name sortKey="Lamarre, J" uniqKey="Lamarre J">J. LaMarre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sinha, P B" uniqKey="Sinha P">P.B. Sinha</name></author><author><name sortKey="Tesfaye, D" uniqKey="Tesfaye D">D. Tesfaye</name></author><author><name sortKey="Rings, F" uniqKey="Rings F">F. Rings</name></author><author><name sortKey="Hossien, M" uniqKey="Hossien M">M. Hossien</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Held, E" uniqKey="Held E">E. Held</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Schellander, K" uniqKey="Schellander K">K. Schellander</name></author><author><name sortKey="Salilew Wondim, D" uniqKey="Salilew Wondim D">D. Salilew-Wondim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maalouf, S W" uniqKey="Maalouf S">S.W. Maalouf</name></author><author><name sortKey="Smith, C L" uniqKey="Smith C">C.L. Smith</name></author><author><name sortKey="Pate, J L" uniqKey="Pate J">J.L. Pate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jerome, A" uniqKey="Jerome A">A. Jerome</name></author><author><name sortKey="Thirumaran, S M K" uniqKey="Thirumaran S">S.M.K. Thirumaran</name></author><author><name sortKey="Kala, S N" uniqKey="Kala S">S.N. Kala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia L Pez, J" uniqKey="Garcia L Pez J">J. García-López</name></author><author><name sortKey="Del Mazo, J" uniqKey="Del Mazo J">J. del Mazo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, S" uniqKey="Yuan S">S. Yuan</name></author><author><name sortKey="Schuster, A" uniqKey="Schuster A">A. Schuster</name></author><author><name sortKey="Tang, C" uniqKey="Tang C">C. Tang</name></author><author><name sortKey="Yu, T" uniqKey="Yu T">T. Yu</name></author><author><name sortKey="Ortogero, N" uniqKey="Ortogero N">N. Ortogero</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J. Bao</name></author><author><name sortKey="Zheng, H" uniqKey="Zheng H">H. Zheng</name></author><author><name sortKey="Yan, W" uniqKey="Yan W">W. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Q" uniqKey="Yang Q">Q. Yang</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name></author><author><name sortKey="Li, R" uniqKey="Li R">R. Li</name></author><author><name sortKey="Tian, B" uniqKey="Tian B">B. Tian</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Xu, B" uniqKey="Xu B">B. Xu</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, M" uniqKey="Yang M">M. Yang</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y. Yao</name></author><author><name sortKey="Eades, G" uniqKey="Eades G">G. Eades</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author><author><name sortKey="Teng, Y" uniqKey="Teng Y">Y. Teng</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narasimhan, M" uniqKey="Narasimhan M">M. Narasimhan</name></author><author><name sortKey="Riar, A K" uniqKey="Riar A">A.K. Riar</name></author><author><name sortKey="Rathinam, M L" uniqKey="Rathinam M">M.L. Rathinam</name></author><author><name sortKey="Vedpathak, D" uniqKey="Vedpathak D">D. Vedpathak</name></author><author><name sortKey="Henderson, G" uniqKey="Henderson G">G. Henderson</name></author><author><name sortKey="Mahimainathan, L" uniqKey="Mahimainathan L">L. Mahimainathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narasimhan, M" uniqKey="Narasimhan M">M. Narasimhan</name></author><author><name sortKey="Patel, D" uniqKey="Patel D">D. Patel</name></author><author><name sortKey="Vedpathak, D" uniqKey="Vedpathak D">D. Vedpathak</name></author><author><name sortKey="Rathinam, M" uniqKey="Rathinam M">M. Rathinam</name></author><author><name sortKey="Henderson, G" uniqKey="Henderson G">G. Henderson</name></author><author><name sortKey="Mahimainathan, L" uniqKey="Mahimainathan L">L. Mahimainathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, W" uniqKey="Yang W">W. Yang</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y. Shen</name></author><author><name sortKey="Wei, J" uniqKey="Wei J">J. Wei</name></author><author><name sortKey="Liu, F" uniqKey="Liu F">F. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ji, Q" uniqKey="Ji Q">Q. Ji</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J. Gao</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y. Zheng</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name></author><author><name sortKey="Shi, C" uniqKey="Shi C">C. Shi</name></author><author><name sortKey="Yao, M" uniqKey="Yao M">M. Yao</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mierziak, J" uniqKey="Mierziak J">J. Mierziak</name></author><author><name sortKey="Wojtasik, W" uniqKey="Wojtasik W">W. Wojtasik</name></author><author><name sortKey="Kostyn, K" uniqKey="Kostyn K">K. Kostyn</name></author><author><name sortKey="Czuj, T" uniqKey="Czuj T">T. Czuj</name></author><author><name sortKey="Szopa, J" uniqKey="Szopa J">J. Szopa</name></author><author><name sortKey="Kulma, A" uniqKey="Kulma A">A. Kulma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morel, I" uniqKey="Morel I">I. Morel</name></author><author><name sortKey="Lescoat, G" uniqKey="Lescoat G">G. Lescoat</name></author><author><name sortKey="Cogrel, P" uniqKey="Cogrel P">P. Cogrel</name></author><author><name sortKey="Sergent, O" uniqKey="Sergent O">O. Sergent</name></author><author><name sortKey="Pasdeloup, N" uniqKey="Pasdeloup N">N. Pasdeloup</name></author><author><name sortKey="Brissot, P" uniqKey="Brissot P">P. Brissot</name></author><author><name sortKey="Cillard, P" uniqKey="Cillard P">P. Cillard</name></author><author><name sortKey="Cillard, J" uniqKey="Cillard J">J. Cillard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vasilescu, D" uniqKey="Vasilescu D">D. Vasilescu</name></author><author><name sortKey="Girma, R" uniqKey="Girma R">R. Girma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, N" uniqKey="Ghosh N">N. Ghosh</name></author><author><name sortKey="Chakraborty, T" uniqKey="Chakraborty T">T. Chakraborty</name></author><author><name sortKey="Mallick, S" uniqKey="Mallick S">S. Mallick</name></author><author><name sortKey="Mana, S" uniqKey="Mana S">S. Mana</name></author><author><name sortKey="Singha, D" uniqKey="Singha D">D. Singha</name></author><author><name sortKey="Ghosh, B" uniqKey="Ghosh B">B. Ghosh</name></author><author><name sortKey="Roy, S" uniqKey="Roy S">S. Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naderi, G A" uniqKey="Naderi G">G.A. Naderi</name></author><author><name sortKey="Asgary, S" uniqKey="Asgary S">S. Asgary</name></author><author><name sortKey="Sarraf Zadegan, N" uniqKey="Sarraf Zadegan N">N. Sarraf-Zadegan</name></author><author><name sortKey="Shirvany, H" uniqKey="Shirvany H">H. Shirvany</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M R" uniqKey="Kim M">M.-R. Kim</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Lee, H H" uniqKey="Lee H">H.-H. Lee</name></author><author><name sortKey="Aryal, D K" uniqKey="Aryal D">D.K. Aryal</name></author><author><name sortKey="Kim, Y G" uniqKey="Kim Y">Y.G. Kim</name></author><author><name sortKey="Kim, S K" uniqKey="Kim S">S.K. Kim</name></author><author><name sortKey="Woo, E R" uniqKey="Woo E">E.-R. Woo</name></author><author><name sortKey="Kang, K W" uniqKey="Kang K">K.W. Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bao, D" uniqKey="Bao D">D. Bao</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Pang, X" uniqKey="Pang X">X. Pang</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, T" uniqKey="Yang T">T. Yang</name></author><author><name sortKey="Kong, B" uniqKey="Kong B">B. Kong</name></author><author><name sortKey="Gu, J W" uniqKey="Gu J">J.-W. Gu</name></author><author><name sortKey="Kuang, Y Q" uniqKey="Kuang Y">Y.-Q. Kuang</name></author><author><name sortKey="Cheng, L" uniqKey="Cheng L">L. Cheng</name></author><author><name sortKey="Yang, W T" uniqKey="Yang W">W.-T. Yang</name></author><author><name sortKey="Xia, X" uniqKey="Xia X">X. Xia</name></author><author><name sortKey="Shu, H F" uniqKey="Shu H">H.-F. Shu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, C H" uniqKey="Kang C">C.-H. Kang</name></author><author><name sortKey="Choi, Y H" uniqKey="Choi Y">Y.H. Choi</name></author><author><name sortKey="Moon, S K" uniqKey="Moon S">S.-K. Moon</name></author><author><name sortKey="Kim, W J" uniqKey="Kim W">W.-J. Kim</name></author><author><name sortKey="Kim, G Y" uniqKey="Kim G">G.-Y. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saw, C L L" uniqKey="Saw C">C.L.L. Saw</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Yang, A Y" uniqKey="Yang A">A.Y. Yang</name></author><author><name sortKey="Paredes Gonzalez, X" uniqKey="Paredes Gonzalez X">X. Paredes-Gonzalez</name></author><author><name sortKey="Ramirez, C" uniqKey="Ramirez C">C. Ramirez</name></author><author><name sortKey="Pung, D" uniqKey="Pung D">D. Pung</name></author><author><name sortKey="Kong, A N T" uniqKey="Kong A">A.-N.T. Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, G Y" uniqKey="Sun G">G.Y. Sun</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Jasmer, K J" uniqKey="Jasmer K">K.J. Jasmer</name></author><author><name sortKey="Chuang, D Y" uniqKey="Chuang D">D.Y. Chuang</name></author><author><name sortKey="Gu, Z" uniqKey="Gu Z">Z. Gu</name></author><author><name sortKey="Hannink, M" uniqKey="Hannink M">M. Hannink</name></author><author><name sortKey="Simonyi, A" uniqKey="Simonyi A">A. Simonyi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chun, K S" uniqKey="Chun K">K.-S. Chun</name></author><author><name sortKey="Kundu, J" uniqKey="Kundu J">J. Kundu</name></author><author><name sortKey="Kundu, J K" uniqKey="Kundu J">J.K. Kundu</name></author><author><name sortKey="Surh, Y J" uniqKey="Surh Y">Y.-J. Surh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murakami, A" uniqKey="Murakami A">A. Murakami</name></author><author><name sortKey="Ashida, H" uniqKey="Ashida H">H. Ashida</name></author><author><name sortKey="Terao, J" uniqKey="Terao J">J. Terao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ji, L L" uniqKey="Ji L">L.-L. Ji</name></author><author><name sortKey="Sheng, Y C" uniqKey="Sheng Y">Y.-C. Sheng</name></author><author><name sortKey="Zheng, Z Y" uniqKey="Zheng Z">Z.-Y. Zheng</name></author><author><name sortKey="Shi, L" uniqKey="Shi L">L. Shi</name></author><author><name sortKey="Wang, Z T" uniqKey="Wang Z">Z.-T. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H. Ghanim</name></author><author><name sortKey="Sia, C L" uniqKey="Sia C">C.L. Sia</name></author><author><name sortKey="Korzeniewski, K" uniqKey="Korzeniewski K">K. Korzeniewski</name></author><author><name sortKey="Lohano, T" uniqKey="Lohano T">T. Lohano</name></author><author><name sortKey="Abuaysheh, S" uniqKey="Abuaysheh S">S. Abuaysheh</name></author><author><name sortKey="Marumganti, A" uniqKey="Marumganti A">A. Marumganti</name></author><author><name sortKey="Chaudhuri, A" uniqKey="Chaudhuri A">A. Chaudhuri</name></author><author><name sortKey="Dandona, P" uniqKey="Dandona P">P. Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, A N" uniqKey="Pandey A">A.N. Pandey</name></author><author><name sortKey="Tripathi, A" uniqKey="Tripathi A">A. Tripathi</name></author><author><name sortKey="Premkumar, K V" uniqKey="Premkumar K">K.V. Premkumar</name></author><author><name sortKey="Shrivastav, T G" uniqKey="Shrivastav T">T.G. Shrivastav</name></author><author><name sortKey="Chaube, S K" uniqKey="Chaube S">S.K. Chaube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shkolnik, K" uniqKey="Shkolnik K">K. Shkolnik</name></author><author><name sortKey="Tadmor, A" uniqKey="Tadmor A">A. Tadmor</name></author><author><name sortKey="Ben Dor, S" uniqKey="Ben Dor S">S. Ben-Dor</name></author><author><name sortKey="Nevo, N" uniqKey="Nevo N">N. Nevo</name></author><author><name sortKey="Galiani, D" uniqKey="Galiani D">D. Galiani</name></author><author><name sortKey="Dekel, N" uniqKey="Dekel N">N. Dekel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finkel, T" uniqKey="Finkel T">T. Finkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cordeiro, M B C" uniqKey="Cordeiro M">M.B.C. Cordeiro</name></author><author><name sortKey="Antonelli, E J" uniqKey="Antonelli E">E.J. Antonelli</name></author><author><name sortKey="Da Cunha, D F" uniqKey="Da Cunha D">D.F. da Cunha</name></author><author><name sortKey="Junior, A A J" uniqKey="Junior A">A.A.J. Júnior</name></author><author><name sortKey="Junior, V R" uniqKey="Junior V">V.R. Júnior</name></author><author><name sortKey="Vannucchi, H" uniqKey="Vannucchi H">H. Vannucchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Betteridge, D J" uniqKey="Betteridge D">D.J. Betteridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Romero, F J" uniqKey="Martin Romero F">F.J. Martín-Romero</name></author><author><name sortKey="Miguel Lasobras, E M" uniqKey="Miguel Lasobras E">E.M. Miguel-Lasobras</name></author><author><name sortKey="Dominguez Arroyo, J A" uniqKey="Dominguez Arroyo J">J.A. Domínguez-Arroyo</name></author><author><name sortKey="Gonzalez Carrera, E" uniqKey="Gonzalez Carrera E">E. González-Carrera</name></author><author><name sortKey="Alvarez, I S" uniqKey="Alvarez I">I.S. Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tripathi, A" uniqKey="Tripathi A">A. Tripathi</name></author><author><name sortKey="Khatun, S" uniqKey="Khatun S">S. Khatun</name></author><author><name sortKey="Pandey, A N" uniqKey="Pandey A">A.N. Pandey</name></author><author><name sortKey="Mishra, S K" uniqKey="Mishra S">S.K. Mishra</name></author><author><name sortKey="Chaube, R" uniqKey="Chaube R">R. Chaube</name></author><author><name sortKey="Shrivastav, T G" uniqKey="Shrivastav T">T.G. Shrivastav</name></author><author><name sortKey="Chaube, S K" uniqKey="Chaube S">S.K. Chaube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujii, J" uniqKey="Fujii J">J. Fujii</name></author><author><name sortKey="Iuchi, Y" uniqKey="Iuchi Y">Y. Iuchi</name></author><author><name sortKey="Okada, F" uniqKey="Okada F">F. Okada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, L" uniqKey="Shi L">L. Shi</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Lai, Z" uniqKey="Lai Z">Z. Lai</name></author><author><name sortKey="Tian, Y" uniqKey="Tian Y">Y. Tian</name></author><author><name sortKey="Fang, L" uniqKey="Fang L">L. Fang</name></author><author><name sortKey="Wu, M" uniqKey="Wu M">M. Wu</name></author><author><name sortKey="Xiong, J" uniqKey="Xiong J">J. Xiong</name></author><author><name sortKey="Qin, X" uniqKey="Qin X">X. Qin</name></author><author><name sortKey="Luo, A" uniqKey="Luo A">A. Luo</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, Z" uniqKey="Fan Z">Z. Fan</name></author><author><name sortKey="Wirth, A K" uniqKey="Wirth A">A.-K. Wirth</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D. Chen</name></author><author><name sortKey="Wruck, C J" uniqKey="Wruck C">C.J. Wruck</name></author><author><name sortKey="Rauh, M" uniqKey="Rauh M">M. Rauh</name></author><author><name sortKey="Buchfelder, M" uniqKey="Buchfelder M">M. Buchfelder</name></author><author><name sortKey="Savaskan, N" uniqKey="Savaskan N">N. Savaskan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Homma, S" uniqKey="Homma S">S. Homma</name></author><author><name sortKey="Ishii, Y" uniqKey="Ishii Y">Y. Ishii</name></author><author><name sortKey="Morishima, Y" uniqKey="Morishima Y">Y. Morishima</name></author><author><name sortKey="Yamadori, T" uniqKey="Yamadori T">T. Yamadori</name></author><author><name sortKey="Matsuno, Y" uniqKey="Matsuno Y">Y. Matsuno</name></author><author><name sortKey="Haraguchi, N" uniqKey="Haraguchi N">N. Haraguchi</name></author><author><name sortKey="Kikuchi, N" uniqKey="Kikuchi N">N. Kikuchi</name></author><author><name sortKey="Satoh, H" uniqKey="Satoh H">H. Satoh</name></author><author><name sortKey="Sakamoto, T" uniqKey="Sakamoto T">T. Sakamoto</name></author><author><name sortKey="Hizawa, N" uniqKey="Hizawa N">N. Hizawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duffy, J Y" uniqKey="Duffy J">J.Y. Duffy</name></author><author><name sortKey="Hughes, M" uniqKey="Hughes M">M. Hughes</name></author><author><name sortKey="Asnes, A G" uniqKey="Asnes A">A.G. Asnes</name></author><author><name sortKey="Leventhal, J M" uniqKey="Leventhal J">J.M. Leventhal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmstrom, K M" uniqKey="Holmstrom K">K.M. Holmström</name></author><author><name sortKey="Baird, L" uniqKey="Baird L">L. Baird</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Hargreaves, I" uniqKey="Hargreaves I">I. Hargreaves</name></author><author><name sortKey="Chalasani, A" uniqKey="Chalasani A">A. Chalasani</name></author><author><name sortKey="Land, J M" uniqKey="Land J">J.M. Land</name></author><author><name sortKey="Stanyer, L" uniqKey="Stanyer L">L. Stanyer</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name></author><author><name sortKey="Dinkova Kostova, A T" uniqKey="Dinkova Kostova A">A.T. Dinkova-Kostova</name></author><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A.Y. Abramov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayers, D" uniqKey="Ayers D">D. Ayers</name></author><author><name sortKey="Baron, B" uniqKey="Baron B">B. Baron</name></author><author><name sortKey="Hunter, T" uniqKey="Hunter T">T. Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papp, D" uniqKey="Papp D">D. Papp</name></author><author><name sortKey="Lenti, K" uniqKey="Lenti K">K. Lenti</name></author><author><name sortKey="M Dos, D" uniqKey="M Dos D">D. Módos</name></author><author><name sortKey="Fazekas, D" uniqKey="Fazekas D">D. Fazekas</name></author><author><name sortKey="Dul, Z" uniqKey="Dul Z">Z. Dúl</name></author><author><name sortKey="Turei, D" uniqKey="Turei D">D. Türei</name></author><author><name sortKey="Foldvari Nagy, L" uniqKey="Foldvari Nagy L">L. Földvári-Nagy</name></author><author><name sortKey="Nussinov, R" uniqKey="Nussinov R">R. Nussinov</name></author><author><name sortKey="Csermely, P" uniqKey="Csermely P">P. Csermely</name></author><author><name sortKey="Korcsmaros, T" uniqKey="Korcsmaros T">T. Korcsmáros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, B" uniqKey="Singh B">B. Singh</name></author><author><name sortKey="Ronghe, A M" uniqKey="Ronghe A">A.M. Ronghe</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A. Chatterjee</name></author><author><name sortKey="Bhat, N K" uniqKey="Bhat N">N.K. Bhat</name></author><author><name sortKey="Bhat, H K" uniqKey="Bhat H">H.K. Bhat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poljsak, B" uniqKey="Poljsak B">B. Poljšak</name></author><author><name sortKey="Fink, R" uniqKey="Fink R">R. Fink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castillo, C" uniqKey="Castillo C">C. Castillo</name></author><author><name sortKey="Pereira, V" uniqKey="Pereira V">V. Pereira</name></author><author><name sortKey="Abuelo, A" uniqKey="Abuelo A">Á. Abuelo</name></author><author><name sortKey="Hernandez, J" uniqKey="Hernandez J">J. Hernández</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar Mishra, S" uniqKey="Kumar Mishra S">S. Kumar Mishra</name></author><author><name sortKey="Singh, P" uniqKey="Singh P">P. Singh</name></author><author><name sortKey="Rath, S K" uniqKey="Rath S">S.K. Rath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, H N" uniqKey="Choi H">H.-N. Choi</name></author><author><name sortKey="Jeong, S M" uniqKey="Jeong S">S.-M. Jeong</name></author><author><name sortKey="Huh, G H" uniqKey="Huh G">G.H. Huh</name></author><author><name sortKey="Kim, J I" uniqKey="Kim J">J.-I. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naseer, Z" uniqKey="Naseer Z">Z. Naseer</name></author><author><name sortKey="Ahmad, E" uniqKey="Ahmad E">E. Ahmad</name></author><author><name sortKey="Epikmen, E T" uniqKey="Epikmen E">E.T. Epikmen</name></author><author><name sortKey="Ucan, U" uniqKey="Ucan U">U. Uçan</name></author><author><name sortKey="Boyacio Lu, M" uniqKey="Boyacio Lu M">M. Boyacioğlu</name></author><author><name sortKey=" Pek, E" uniqKey=" Pek E">E. İpek</name></author><author><name sortKey="Akosy, M" uniqKey="Akosy M">M. Akosy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arredondo, F" uniqKey="Arredondo F">F. Arredondo</name></author><author><name sortKey="Echeverry, C" uniqKey="Echeverry C">C. Echeverry</name></author><author><name sortKey="Abin Carriquiry, J A" uniqKey="Abin Carriquiry J">J.A. Abin-Carriquiry</name></author><author><name sortKey="Blasina, F" uniqKey="Blasina F">F. Blasina</name></author><author><name sortKey="Antunez, K" uniqKey="Antunez K">K. Antúnez</name></author><author><name sortKey="Jones, D P" uniqKey="Jones D">D.P. Jones</name></author><author><name sortKey="Go, Y M" uniqKey="Go Y">Y.-M. Go</name></author><author><name sortKey="Liang, Y L" uniqKey="Liang Y">Y.-L. Liang</name></author><author><name sortKey="Dajas, F" uniqKey="Dajas F">F. Dajas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pallauf, K" uniqKey="Pallauf K">K. Pallauf</name></author><author><name sortKey="Duckstein, N" uniqKey="Duckstein N">N. Duckstein</name></author><author><name sortKey="Hasler, M" uniqKey="Hasler M">M. Hasler</name></author><author><name sortKey="Klotz, L O" uniqKey="Klotz L">L.-O. Klotz</name></author><author><name sortKey="Rimbach, G" uniqKey="Rimbach G">G. Rimbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Kim, C S" uniqKey="Kim C">C.-S. Kim</name></author><author><name sortKey="Joe, Y" uniqKey="Joe Y">Y. Joe</name></author><author><name sortKey="Chung, H T" uniqKey="Chung H">H.T. Chung</name></author><author><name sortKey="Ha, T Y" uniqKey="Ha T">T.Y. Ha</name></author><author><name sortKey="Yu, R" uniqKey="Yu R">R. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robledinos Ant N, N" uniqKey="Robledinos Ant N N">N. Robledinos-Antón</name></author><author><name sortKey="Rojo, A I" uniqKey="Rojo A">A.I. Rojo</name></author><author><name sortKey="Ferreiro, E" uniqKey="Ferreiro E">E. Ferreiro</name></author><author><name sortKey="Nu Ez, A" uniqKey="Nu Ez A">Á. Núñez</name></author><author><name sortKey="Krause, K H" uniqKey="Krause K">K.-H. Krause</name></author><author><name sortKey="Jaquet, V" uniqKey="Jaquet V">V. Jaquet</name></author><author><name sortKey="Cuadrado, A" uniqKey="Cuadrado A">A. Cuadrado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robaszkiewicz, A" uniqKey="Robaszkiewicz A">A. Robaszkiewicz</name></author><author><name sortKey="Balcerczyk, A" uniqKey="Balcerczyk A">A. Balcerczyk</name></author><author><name sortKey="Bartosz, G" uniqKey="Bartosz G">G. Bartosz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Marchi, U" uniqKey="De Marchi U">U. de Marchi</name></author><author><name sortKey="Biasutto, L" uniqKey="Biasutto L">L. Biasutto</name></author><author><name sortKey="Garbisa, S" uniqKey="Garbisa S">S. Garbisa</name></author><author><name sortKey="Toninello, A" uniqKey="Toninello A">A. Toninello</name></author><author><name sortKey="Zoratti, M" uniqKey="Zoratti M">M. Zoratti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Z" uniqKey="Yuan Z">Z. Yuan</name></author><author><name sortKey="Long, C" uniqKey="Long C">C. Long</name></author><author><name sortKey="Junming, T" uniqKey="Junming T">T. Junming</name></author><author><name sortKey="Qihuan, L" uniqKey="Qihuan L">L. Qihuan</name></author><author><name sortKey="Youshun, Z" uniqKey="Youshun Z">Z. Youshun</name></author><author><name sortKey="Chan, Z" uniqKey="Chan Z">Z. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richter, M" uniqKey="Richter M">M. Richter</name></author><author><name sortKey="Ebermann, R" uniqKey="Ebermann R">R. Ebermann</name></author><author><name sortKey="Marian, B" uniqKey="Marian B">B. Marian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Zhao, X H" uniqKey="Zhao X">X.-H. Zhao</name></author><author><name sortKey="Wang, Z J" uniqKey="Wang Z">Z.-J. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suh, D K" uniqKey="Suh D">D.K. Suh</name></author><author><name sortKey="Lee, E J" uniqKey="Lee E">E.J. Lee</name></author><author><name sortKey="Kim, H C" uniqKey="Kim H">H.C. Kim</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J.H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L R" uniqKey="Zhao L">L.-R. Zhao</name></author><author><name sortKey="Du, Y J" uniqKey="Du Y">Y.-J. Du</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author><author><name sortKey="Liu, Z G" uniqKey="Liu Z">Z.-G. Liu</name></author><author><name sortKey="Pan, Y H" uniqKey="Pan Y">Y.-H. Pan</name></author><author><name sortKey="Liu, J F" uniqKey="Liu J">J.-F. Liu</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author><author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H. Lu</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H. Wu</name></author><author><name sortKey="Chai, Y" uniqKey="Chai Y">Y. Chai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanigawa, S" uniqKey="Tanigawa S">S. Tanigawa</name></author><author><name sortKey="Fujii, M" uniqKey="Fujii M">M. Fujii</name></author><author><name sortKey="Hou, D X" uniqKey="Hou D">D.-X. Hou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boesch Saadatmandi, C" uniqKey="Boesch Saadatmandi C">C. Boesch-Saadatmandi</name></author><author><name sortKey="Loboda, A" uniqKey="Loboda A">A. Loboda</name></author><author><name sortKey="Wagner, A E" uniqKey="Wagner A">A.E. Wagner</name></author><author><name sortKey="Stachurska, A" uniqKey="Stachurska A">A. Stachurska</name></author><author><name sortKey="Jozkowicz, A" uniqKey="Jozkowicz A">A. Jozkowicz</name></author><author><name sortKey="Dulak, J" uniqKey="Dulak J">J. Dulak</name></author><author><name sortKey="Doring, F" uniqKey="Doring F">F. Döring</name></author><author><name sortKey="Wolffram, S" uniqKey="Wolffram S">S. Wolffram</name></author><author><name sortKey="Rimbach, G" uniqKey="Rimbach G">G. Rimbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boesch Saadatmandi, C" uniqKey="Boesch Saadatmandi C">C. Boesch-Saadatmandi</name></author><author><name sortKey="Wagner, A E" uniqKey="Wagner A">A.E. Wagner</name></author><author><name sortKey="Wolffram, S" uniqKey="Wolffram S">S. Wolffram</name></author><author><name sortKey="Rimbach, G" uniqKey="Rimbach G">G. Rimbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Guo, Q" uniqKey="Guo Q">Q. Guo</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Del Follo Martinez, A" uniqKey="Del Follo Martinez A">A. Del Follo-Martinez</name></author><author><name sortKey="Banerjee, N" uniqKey="Banerjee N">N. Banerjee</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Safe, S" uniqKey="Safe S">S. Safe</name></author><author><name sortKey="Mertens Talcott, S" uniqKey="Mertens Talcott S">S. Mertens-Talcott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chuammitri, P" uniqKey="Chuammitri P">P. Chuammitri</name></author><author><name sortKey="Srikok, S" uniqKey="Srikok S">S. Srikok</name></author><author><name sortKey="Saipinta, D" uniqKey="Saipinta D">D. Saipinta</name></author><author><name sortKey="Boonyayatra, S" uniqKey="Boonyayatra S">S. Boonyayatra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friedman, R C" uniqKey="Friedman R">R.C. Friedman</name></author><author><name sortKey="Farh, K K H" uniqKey="Farh K">K.K.-H. Farh</name></author><author><name sortKey="Burge, C B" uniqKey="Burge C">C.B. Burge</name></author><author><name sortKey="Bartel, D P" uniqKey="Bartel D">D.P. Bartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agarwal, V" uniqKey="Agarwal V">V. Agarwal</name></author><author><name sortKey="Bell, G W" uniqKey="Bell G">G.W. Bell</name></author><author><name sortKey="Nam, J W" uniqKey="Nam J">J.-W. Nam</name></author><author><name sortKey="Bartel, D P" uniqKey="Bartel D">D.P. Bartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gebremedhn, S" uniqKey="Gebremedhn S">S. Gebremedhn</name></author><author><name sortKey="Salilew Wondim, D" uniqKey="Salilew Wondim D">D. Salilew-Wondim</name></author><author><name sortKey="Ahmad, I" uniqKey="Ahmad I">I. Ahmad</name></author><author><name sortKey="Sahadevan, S" uniqKey="Sahadevan S">S. Sahadevan</name></author><author><name sortKey="Hossain, M M" uniqKey="Hossain M">M.M. Hossain</name></author><author><name sortKey="Hoelker, M" uniqKey="Hoelker M">M. Hoelker</name></author><author><name sortKey="Rings, F" uniqKey="Rings F">F. Rings</name></author><author><name sortKey="Neuhoff, C" uniqKey="Neuhoff C">C. Neuhoff</name></author><author><name sortKey="Tholen, E" uniqKey="Tholen E">E. Tholen</name></author><author><name sortKey="Looft, C" uniqKey="Looft C">C. Looft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, K J" uniqKey="Livak K">K.J. Livak</name></author><author><name sortKey="Schmittgen, T D" uniqKey="Schmittgen T">T.D. Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakamuru, S" uniqKey="Sakamuru S">S. Sakamuru</name></author><author><name sortKey="Attene Ramos, M S" uniqKey="Attene Ramos M">M.S. Attene-Ramos</name></author><author><name sortKey="Xia, M" uniqKey="Xia M">M. Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poot, M" uniqKey="Poot M">M. Poot</name></author><author><name sortKey="Zhang, Y Z" uniqKey="Zhang Y">Y.Z. Zhang</name></author><author><name sortKey="Kr Mer, J A" uniqKey="Kr Mer J">J.A. Krämer</name></author><author><name sortKey="Wells, K S" uniqKey="Wells K">K.S. Wells</name></author><author><name sortKey="Jones, L J" uniqKey="Jones L">L.J. Jones</name></author><author><name sortKey="Hanzel, D K" uniqKey="Hanzel D">D.K. Hanzel</name></author><author><name sortKey="Lugade, A G" uniqKey="Lugade A">A.G. Lugade</name></author><author><name sortKey="Singer, V L" uniqKey="Singer V">V.L. Singer</name></author><author><name sortKey="Haugland, R P" uniqKey="Haugland R">R.P. Haugland</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><noCountry><name sortKey="Gebremedhn, Samuel" sort="Gebremedhn, Samuel" uniqKey="Gebremedhn S" first="Samuel" last="Gebremedhn">Samuel Gebremedhn</name><name sortKey="Khadrawy, Omar" sort="Khadrawy, Omar" uniqKey="Khadrawy O" first="Omar" last="Khadrawy">Omar Khadrawy</name><name sortKey="Neuhoff, Christiane" sort="Neuhoff, Christiane" uniqKey="Neuhoff C" first="Christiane" last="Neuhoff">Christiane Neuhoff</name><name sortKey="Salilew Wondim, Dessie" sort="Salilew Wondim, Dessie" uniqKey="Salilew Wondim D" first="Dessie" last="Salilew-Wondim">Dessie Salilew-Wondim</name><name sortKey="Taqi, Mohamed Omar" sort="Taqi, Mohamed Omar" uniqKey="Taqi M" first="Mohamed Omar" last="Taqi">Mohamed Omar Taqi</name><name sortKey="Tholen, Ernst" sort="Tholen, Ernst" uniqKey="Tholen E" first="Ernst" last="Tholen">Ernst Tholen</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Hoelker, Michael" sort="Hoelker, Michael" uniqKey="Hoelker M" first="Michael" last="Hoelker">Michael Hoelker</name></noRegion><name sortKey="Hoelker, Michael" sort="Hoelker, Michael" uniqKey="Hoelker M" first="Michael" last="Hoelker">Michael Hoelker</name><name sortKey="Schellander, Karl" sort="Schellander, Karl" uniqKey="Schellander K" first="Karl" last="Schellander">Karl Schellander</name><name sortKey="Tesfaye, Dawit" sort="Tesfaye, Dawit" uniqKey="Tesfaye D" first="Dawit" last="Tesfaye">Dawit Tesfaye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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